Abstract
Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A combining with PERV-C-related sequences.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Inbred Strains
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Base Sequence
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Cell Line
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Cells, Cultured
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Coculture Techniques
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Endogenous Retroviruses / genetics*
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Endogenous Retroviruses / physiology*
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Genes, env
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Humans
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Leukocytes, Mononuclear
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Molecular Sequence Data
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Recombination, Genetic
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Sequence Analysis, DNA
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Swine, Miniature / virology*
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Virus Replication
Associated data
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GENBANK/AF417210
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GENBANK/AF417221
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GENBANK/AF417222
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GENBANK/AF417223
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GENBANK/AF417224
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GENBANK/AF417225
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GENBANK/AF417226
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GENBANK/AF417227
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GENBANK/AF417228
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GENBANK/AF417229
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GENBANK/AF417230
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GENBANK/AF417231
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GENBANK/AF417232