Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine

J Virol. 2002 Mar;76(6):3045-8. doi: 10.1128/jvi.76.6.3045-3048.2002.

Abstract

Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A combining with PERV-C-related sequences.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Inbred Strains
  • Base Sequence
  • Cell Line
  • Cells, Cultured
  • Coculture Techniques
  • Endogenous Retroviruses / genetics*
  • Endogenous Retroviruses / physiology*
  • Genes, env
  • Humans
  • Leukocytes, Mononuclear
  • Molecular Sequence Data
  • Recombination, Genetic
  • Sequence Analysis, DNA
  • Swine, Miniature / virology*
  • Virus Replication

Associated data

  • GENBANK/AF417210
  • GENBANK/AF417221
  • GENBANK/AF417222
  • GENBANK/AF417223
  • GENBANK/AF417224
  • GENBANK/AF417225
  • GENBANK/AF417226
  • GENBANK/AF417227
  • GENBANK/AF417228
  • GENBANK/AF417229
  • GENBANK/AF417230
  • GENBANK/AF417231
  • GENBANK/AF417232