MHC class I genes of the tree shrew Tupaia belangeri

Immunogenetics. 2002 Feb;53(10-11):984-8. doi: 10.1007/s00251-001-0401-0. Epub 2002 Jan 9.

Abstract

Two MHC class I cDNA sequences from the tree shrew (Tupaia belangeri), Tube-W01 and Tube-W02, have been isolated which are probably derived from classical class I genes. Expression of the tupaia class I genes was investigated in several organs, in particular the brain, in which slightly different amounts of class I transcripts are detectable in different areas. Gene tree analysis performed with Tube-W01 and Tube-W02, and including class I sequences derived from other orders, indicated that the tupaia sequences cluster differently from Primates, Carnivora, Artiodactyla, Perissodactyla, and Rodentia, but might be related to Lagomorpha class I genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Gene Expression Profiling
  • Genes, MHC Class I / genetics*
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Messenger / metabolism
  • Sequence Homology, Amino Acid
  • Tupaiidae / genetics*
  • Tupaiidae / immunology

Substances

  • RNA, Messenger

Associated data

  • GENBANK/AJ313090
  • GENBANK/AJ313091