Management issues in patients coinfected with hepatitis C virus and HIV

AIDS Read. 2002 Jan;12(1):19-21, 24-6.

Abstract

Coinfection with HIV accelerates the progression of hepatitis C toward advanced liver disease. Low CD4+ cell counts may result in false-negative results on all diagnostic tests except hepatitis C virus (HCV) RNA assays, which are the gold standard for viral replication. First-line management of HIV-HCV--coinfected patients should be optimization of HAART, because low CD4+ cell counts have been associated with greater fibrosis. In addition, agents used to treat hepatitis C may lower CD4+ cell counts and hemoglobin levels. Long-acting interferons offer the promise of better sustained HCV response in HIV-HCV coinfection.

Publication types

  • Lecture

MeSH terms

  • Antiretroviral Therapy, Highly Active
  • Antiviral Agents / therapeutic use*
  • Female
  • HIV Infections / complications*
  • HIV Infections / drug therapy*
  • Hepacivirus / genetics
  • Hepacivirus / isolation & purification
  • Hepatitis A Vaccines / administration & dosage
  • Hepatitis B Vaccines / administration & dosage
  • Hepatitis C / complications*
  • Hepatitis C / diagnosis
  • Hepatitis C / drug therapy*
  • Hepatitis C / physiopathology
  • Humans
  • Interferons / therapeutic use
  • Male
  • RNA, Viral / blood
  • Ribavirin / therapeutic use
  • Vaccination

Substances

  • Antiviral Agents
  • Hepatitis A Vaccines
  • Hepatitis B Vaccines
  • RNA, Viral
  • Ribavirin
  • Interferons