Exploring Prokaryotic Diversity in the Genomic Era

Genome Biol. 2002;3(2):REVIEWS0003. doi: 10.1186/gb-2002-3-2-reviews0003. Epub 2002 Jan 29.

Abstract

Our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes - out of 35 bacterial and 18 archaeal phylum-level lineages. This bias is beginning to be rectified by the use of phylogenetically directed isolation strategies and by directly accessing microbial genomes from environmental samples.

Publication types

  • Review

MeSH terms

  • Actinobacteria / genetics
  • Actinobacteria / isolation & purification
  • Bacteroidaceae / genetics
  • Bacteroidaceae / isolation & purification
  • Genes, Bacterial / genetics*
  • Genetic Variation / genetics*
  • Genome, Bacterial*
  • Gram-Positive Bacteria / genetics
  • Gram-Positive Bacteria / isolation & purification
  • Phylogeny
  • Proteobacteria / genetics
  • Proteobacteria / isolation & purification