Epigenetic reprogramming in the mammalian embryo: struggle of the clones

Genome Biol. 2002;3(2):REVIEWS1003. doi: 10.1186/gb-2002-3-2-reviews1003. Epub 2002 Jan 29.


During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in various mammals showed that the reprogramming that occurs during normal preimplantation development is aberrant in cloned embryos.

Publication types

  • Review

MeSH terms

  • Animals
  • Cloning, Organism
  • DNA Methylation
  • Embryo, Mammalian / chemistry*
  • Embryo, Mammalian / metabolism*
  • Embryo, Nonmammalian*
  • Embryonic Development / genetics
  • Female
  • Genetic Markers / genetics
  • Genomic Imprinting / genetics*
  • Interspersed Repetitive Sequences / genetics
  • Pregnancy


  • Genetic Markers