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Review
, 9 (2), 213-24

CtBP, an Unconventional Transcriptional Corepressor in Development and Oncogenesis

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Review

CtBP, an Unconventional Transcriptional Corepressor in Development and Oncogenesis

G Chinnadurai. Mol Cell.

Abstract

CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.

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