Prostaglandins as Modulators of Immunity

Trends Immunol. 2002 Mar;23(3):144-50. doi: 10.1016/s1471-4906(01)02154-8.

Abstract

Prostaglandins are potent lipid molecules that affect key aspects of immunity. The original view of prostaglandins was that they were simply immunoinhibitory. This review focuses on recent findings concerning prostaglandin E2 (PGE2) and the PGD2 metabolite 15-deoxy-Delta(12,14)-PGJ2, and their divergent roles in immune regulation. We will highlight how these two seminal prostaglandins regulate immunity and inflammation, and play an emerging role in cancer progression. Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adjuvants, Immunologic / physiology*
  • Animals
  • Dinoprostone / biosynthesis
  • Dinoprostone / physiology*
  • Humans
  • Inflammation / immunology
  • Models, Immunological
  • Models, Molecular
  • Neoplasms / immunology
  • Prostaglandin D2 / analogs & derivatives*
  • Prostaglandin D2 / physiology*
  • Prostaglandin-Endoperoxide Synthases / metabolism

Substances

  • 15-deoxy-delta(12,14)-prostaglandin J2
  • Adjuvants, Immunologic
  • Prostaglandin-Endoperoxide Synthases
  • Dinoprostone
  • Prostaglandin D2