In Vitro Bactericidal Activity of Daptomycin Against Staphylococci

J Antimicrob Chemother. 2002 Mar;49(3):467-70. doi: 10.1093/jac/49.3.467.

Abstract

MICs and minimum bactericidal concentrations (MBCs) of daptomycin, vancomycin, linezolid and quinupristin-dalfopristin (Q-D) were determined for 108 staphylococcal isolates. All strains were susceptible (MICs) to daptomycin (< or =2.0 mg/L) and Q-D (< or =1.0 mg/L). All but three isolates were susceptible to vancomycin (< or =4.0 mg/L) and all but one methicillin-resistant Staphylococcus aureus strain were susceptible to linezolid (< or =4.0 mg/L). Q-D had the lowest geometric mean MIC (0.29 mg/L) and daptomycin had the lowest geometric mean MBC (0.57 mg/L). Time-kill tests were performed on 25 isolates. Bactericidal activity (>99.9% kill) was observed with daptomycin at 2 mg/L and at 2 x MBC for 92% of strains tested. In comparison, the bactericidal rates for the other drugs at breakpoint concentrations and at 2 x MBC were 72% and 70% for vancomycin, 46% and 60% for Q-D, and 7% and 14% for linezolid. Of the four drugs tested, daptomycin was bactericidal against the most strains and had the most rapid cidal activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Daptomycin / pharmacology*
  • Drug Therapy, Combination / pharmacology
  • Linezolid
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Oxazolidinones / pharmacology
  • Staphylococcal Infections / microbiology
  • Staphylococcus / drug effects*
  • Staphylococcus / isolation & purification
  • Vancomycin / pharmacology
  • Virginiamycin / pharmacology

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Virginiamycin
  • quinupristin-dalfopristin
  • Vancomycin
  • Linezolid
  • Daptomycin