Seroepidemiology of Chlamydia pneumoniae in Japan between 1991 and 2000

J Clin Pathol. 2002 Feb;55(2):115-7. doi: 10.1136/jcp.55.2.115.


Aim: To clarify the endemic and epidemic status of Chlamydia pneumoniae in Japan, the incidence of anti-C pneumoniae antibody was evaluated over a period of 10 years.

Method: Serum samples were collected from 4756 healthy individuals aged 6 months to 88 years (2488 male and 2268 female individuals) between 1991 and 2000. The antibody titre was determined by a microimmunofluorescence test.

Results: After stratification by age and sex in each year, distinct peaks with prevalences of 73.3% and 73.0% were noted in 1993 and 1999, respectively. The lowest prevalence rate was seen in 1996 (59.0%). The epidemic cycle has been estimated to be almost six years in this geographical area.

Conclusions: Chlamydia pneumoniae infection is highly endemic in Japan, as it is in Western countries, and there is a year to year variability. Long term studies in Japan are needed to clarify the epidemic occurrence of C pneumoniae infection.

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Antibodies, Bacterial / blood*
  • Child
  • Child, Preschool
  • Chlamydophila Infections / diagnosis
  • Chlamydophila Infections / epidemiology*
  • Chlamydophila pneumoniae / immunology*
  • Disease Outbreaks
  • Endemic Diseases
  • Female
  • Humans
  • Incidence
  • Infant
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Seroepidemiologic Studies
  • Sex Distribution


  • Antibodies, Bacterial