Barrett's esophagus and reflux esophagitis: is there a missing link?

Am J Gastroenterol. 2002 Feb;97(2):273-8. doi: 10.1111/j.1572-0241.2002.05454.x.


Objectives: Barrett's esophagus (BE) is associated with esophageal reflux. The development stage of BE is not well described. Epidemiological evidence indicates that the columnar epithelium in BE is acquired and reaches its full length rapidly. We tested the hypothesis that BE might result from direct replacement of erosions in reflux esophagitis (RE).

Methods: At endoscopy, we compared the length and distribution of esophageal erosions in 50 patients with RE with the length and distribution of columnar epithelium in 50 patients with BE.

Results: The median length of erosions in RE was 2 cm, less than the median length of columnar epithelium in BE, 5 cm (p < 0.001). Erosions in RE were usually multiple and scattered, involving the entire circumference of the esophagus in only 10% of cases, but circumferential involvement by columnar epithelium was found in 68% of BE cases (p < 0.001). Circumferential involvement, 3 cm or longer, was found in 0% of cases of RE versus 56% of BE cases (p < 0.001). Two patients without RE or BE had large areas of epithelial loss of uncertain etiology.

Conclusions: The length and distribution of erosions in RE differ greatly from the length and distribution of columnar epithelium in BE. It is unlikely that BE arises directly from areas of esophagitis. We suggest that BE may develop after loss of a long segment of squamous epithelium, with columnar replacement in the presence of continuing acid reflux.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Barrett Esophagus / epidemiology*
  • Barrett Esophagus / pathology*
  • Biopsy, Needle
  • Comorbidity
  • Esophagitis, Peptic / epidemiology*
  • Esophagitis, Peptic / pathology*
  • Esophagoscopy / methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mucous Membrane / pathology
  • Prognosis
  • Prospective Studies
  • Risk Assessment
  • Severity of Illness Index