SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating

J Am Chem Soc. 2002 Mar 6;124(9):1848-9. doi: 10.1021/ja016784d.

Abstract

The design, synthesis, and characterization of a synthetic chloride membrane transporter, SCMTR (synthetic chloride membrane transporter, "scimitar"), are presented. The compound [CH3(CH2)17]2NCOCH2OCH2CO-GGGPGGG-OBzl inserts rapidly into liposomes and planar lipid bilayers. SCMTR has a 1.3 +/- 0.01 nS chloride diffusion pathway (>10:1 Cl/K selectivity). Evidence was also obtained for voltage gating behavior.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chloride Channels / chemical synthesis*
  • Chloride Channels / chemistry
  • Ion Channel Gating*
  • Lipid Bilayers / chemistry
  • Liposomes / chemistry
  • Membrane Potentials
  • Phospholipids / chemistry

Substances

  • Chloride Channels
  • Lipid Bilayers
  • Liposomes
  • Phospholipids