High-quality life extension by the enzyme peptide methionine sulfoxide reductase

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2748-53. doi: 10.1073/pnas.032671199. Epub 2002 Feb 26.


Cumulative oxidative damages to cell constituents are considered to contribute to aging and age-related diseases. The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the repair of oxidized methionine in proteins by reducing methionine sulfoxide back to methionine. However, whether MSRA plays a role in the aging process is poorly understood. Here we report that overexpression of the msrA gene predominantly in the nervous system markedly extends the lifespan of the fruit fly Drosophila. The MSRA transgenic animals are more resistant to paraquat-induced oxidative stress, and the onset of senescence-induced decline in the general activity level and reproductive capacity is delayed markedly. The results suggest that oxidative damage is an important determinant of lifespan, and MSRA may be important in increasing the lifespan in other organisms including humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / physiology
  • Longevity* / physiology
  • Methionine Sulfoxide Reductases
  • Oxidoreductases / genetics
  • Oxidoreductases / physiology*
  • Peptides


  • Peptides
  • Oxidoreductases
  • Methionine Sulfoxide Reductases
  • methionine sulfoxide reductase