Regulation of cell cycle stage-specific transcription of histone genes from chromatin by non-histone chromosomal proteins

Nature. 1975 Oct 30;257(5529):764-7. doi: 10.1038/257764a0.

Abstract

RNA transcripts from chromatin of S phase but not G1 cells contain histone-specific sequences. Chromatin reconstituted with S phase non-histone chromosomal proteins transcribes histone messenger RNA sequences whereas chromatin reconstituted with G1 non-histone proteins does not. These results suggest that transcription of histone genes is regulated during the cell cycle and that non-histone proteins have a key role in this regulation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Division*
  • Cell-Free System
  • Chromatin / metabolism*
  • Chromosomes / metabolism
  • Deoxyribonucleoproteins / metabolism*
  • HeLa Cells
  • Histones / biosynthesis*
  • Nucleoproteins / metabolism*
  • Transcription, Genetic*

Substances

  • Chromatin
  • Deoxyribonucleoproteins
  • Histones
  • Nucleoproteins