Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation

Immunity. 2002 Feb;16(2):219-30. doi: 10.1016/s1074-7613(02)00274-1.


B cells possess a variety of immune functions that are involved in normal and abnormal immune responses, including autoimmune disorders. Through murine models of intestinal inflammation, we here demonstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by CD1d upregulation. This B cell subset appears under a chronic inflammatory environment, produces IL-10, and suppresses progression of intestinal inflammation by downregulating inflammatory cascades associated with IL-1 upregulation and STAT3 activation rather than by altering polarized T helper responses. This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, CD1 / genetics
  • Antigens, CD1 / immunology*
  • Antigens, CD1d
  • B-Lymphocyte Subsets / immunology*
  • Chronic Disease
  • Colitis / immunology*
  • Colitis / pathology
  • Colon / immunology*
  • Colon / pathology
  • Disease Progression
  • Female
  • Interleukin-10 / biosynthesis*
  • Interleukin-10 / genetics
  • Lymphoid Tissue / cytology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Up-Regulation / immunology*


  • Antigens, CD1
  • Antigens, CD1d
  • Interleukin-10