Nickel-catalyzed coupling of aryl iodides with aromatic aldehydes: chemoselective synthesis of ketones

Yi-Chun Huang; Kanak Kanti Majumdar; Chien-Hong Cheng

doi:10.1021/jo010289i

Nickel-catalyzed coupling of aryl iodides with aromatic aldehydes: chemoselective synthesis of ketones

J Org Chem. 2002 Mar 8;67(5):1682-4. doi: 10.1021/jo010289i.

Authors

Yi-Chun Huang¹, Kanak Kanti Majumdar, Chien-Hong Cheng

Affiliation

¹ Department of Chemistry, Tsing Hua University, Hsinchu, Taiwan 300.

PMID: 11871903
DOI: 10.1021/jo010289i

Abstract

Aryl iodides (ArI) couple with aryl aldehydes (Ar'CHO) in the presence of Ni(dppe)Br(2) and Zn to give the corresponding biaryl ketones (ArCOAr'). The use of a bidentate phosphine complex is critical to the success of this catalytic reaction. The reaction provides a new procedure for the synthesis of various functionalized biaryl ketones.