An unusual case of cutaneous plasmacytoma with multiple lesions in a 77-year-old man affected by chronic lymphoedema of his lower limbs is reported. Histopathology and immunohistochemical staining led to the diagnosis of cutaneous plasmacytoma. Staging studies were not able to identify extracutaneous involvement. The lesions were successfully treated with melphalan and prednisone. No signs of progression of the disease were seen at a 2- year follow-up.