Type 1 diabetes mellitus and epilepsia partialis continua in a 6-year-old boy with elevated anti-GAD65 antibodies

Pediatrics. 2002 Mar;109(3):E50. doi: 10.1542/peds.109.3.e50.

Abstract

A 6-year-old boy presented with epilepsia partialis continua 6 months after diagnosis of type 1 diabetes. Anti-glutamic acid decarboxylase 65 antibodies were found in his serum and cerebrospinal fluid. Anti-epileptic agents did not improve his seizures. High-dose steroids, plasmapheresis, and intravenous immunoglobulin resulted in decreased anti-glutamic acid decarboxylase 65 antibody levels and resolution of his seizures.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / blood*
  • Brain / pathology
  • Child
  • Combined Modality Therapy
  • Diabetes Mellitus, Type 1 / immunology*
  • Epilepsia Partialis Continua / immunology*
  • Epilepsia Partialis Continua / therapy
  • Glutamate Decarboxylase / immunology*
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Isoenzymes / immunology*
  • Male
  • Plasmapheresis
  • Prednisolone / therapeutic use

Substances

  • Autoantibodies
  • Immunoglobulins, Intravenous
  • Isoenzymes
  • Prednisolone
  • Glutamate Decarboxylase
  • glutamate decarboxylase 2