A rendezvous before rejection: where do T cells meet transplant antigens?

Nat Med. 2002 Mar;8(3):220-2. doi: 10.1038/nm0302-220.


Interactions between recipient T cells and donor endothelial graft cells may be an important mechanism for both acute and chronic rejection of vascularized allografts. This finding provides a starting point for investigations to develop novel ways of inducing long-lasting immunologic tolerance to donor antigens.

Publication types

  • Comment
  • News

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Antigen Presentation
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / immunology*
  • Graft Rejection / immunology*
  • Histocompatibility Antigens / immunology*
  • Histocompatibility Antigens / metabolism
  • Humans
  • Models, Immunological
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism
  • Transplantation, Homologous


  • Histocompatibility Antigens