Adaptive protein evolution in Drosophila

Nature. 2002 Feb 28;415(6875):1022-4. doi: 10.1038/4151022a.


For over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level. Evidence has accumulated over the last decade that adaptive evolution does occur at the protein level, but it has remained unclear how prevalent adaptive evolution is. Here we present a simple method by which the number of adaptive substitutions can be estimated and apply it to data from Drosophila simulans and D. yakuba. We estimate that 45% of all amino-acid substitutions have been fixed by natural selection, and that on average one adaptive substitution occurs every 45 years in these species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Biological*
  • Amino Acid Substitution
  • Animals
  • Computer Simulation
  • Drosophila / genetics*
  • Drosophila / physiology
  • Drosophila Proteins / genetics*
  • Drosophila Proteins / physiology
  • Evolution, Molecular*
  • Genes, Insect
  • Models, Genetic
  • Polymorphism, Genetic
  • Selection, Genetic*


  • Drosophila Proteins