Spatial and temporal pattern of Fgf-8 expression during chicken development

Anat Embryol (Berl). 2002 Jan;205(1):1-6. doi: 10.1007/s00429-002-0227-z.


This study analyzes the temporal and spatial expression pattern of Fgf-8 over a continuous series of developmental stages. Special emphasis is laid on the paraxial mesoderm where Fgf-8 expression is highly dynamic. Whereas the anterior portion of the unsegmented mesoderm is devoid of expression, Fgf-8 is upregulated in the posterior half of a newly formed somite. Soon after somite formation, this highly localized expression gives way to a more diffuse pattern of Fgf-8 expression at low levels in presumptive sclerotomal cells. During later somite maturation, transcripts become restricted to the myotome. Co-staining with the myotome marker MyoD reveals that Fgf-8 expression defines a subpopulation of muscle precursor cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chick Embryo / physiology*
  • Embryonic and Fetal Development
  • Fibroblast Growth Factor 8
  • Fibroblast Growth Factors / genetics*
  • Fibroblast Growth Factors / metabolism
  • Gene Expression Regulation, Developmental*
  • In Situ Hybridization
  • Morphogenesis / genetics
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism
  • RNA, Messenger / metabolism
  • Somites / metabolism


  • Neoplasm Proteins
  • RNA, Messenger
  • Fibroblast Growth Factor 8
  • Fibroblast Growth Factors