Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale)

Methods Find Exp Clin Pharmacol. 2001 Nov;23(9):501-3. doi: 10.1358/mf.2001.23.9.662137.

Abstract

The effects of the acetone extract of ginger (Zingiber officinale) was studied against pyrogallol-induced delay in gastric emptying in rats. Wistar rats of either sex, weighing between 200-250 g, were used. Pyrogallol, at a dose of 100 mg/kg i.p., significantly delayed the gastric emptying of a methyl cellulose meal. One-hour pretreatment with ginger acetone extracts (100, 250 and 500 mg/kg p.o.) reversed the pyrogallol-induced delay in gastric emptying. The effect was significant at doses of 250 and 500 mg/kg. When the low dose of ginger (100 mg/kg p.o.) was given with vitamin C and vitamin E (100 mg/kg p.o., each), the reversal of gastric emptying was more pronounced than when only two vitamins or ginger (100 mg/kg and 500 mg/kg) were given alone. The present study indicates the potential of ginger in improving symptoms such as abdominal discomfort and bloating, which may accompany several gastrointestinal illnesses.

MeSH terms

  • Animals
  • Ascorbic Acid / pharmacology
  • Female
  • Free Radicals
  • Gastric Emptying / drug effects*
  • Ginger*
  • Male
  • Plant Extracts / pharmacology*
  • Pyrogallol / pharmacology*
  • Rats
  • Rats, Wistar
  • Vitamin E / pharmacology

Substances

  • Free Radicals
  • Plant Extracts
  • Pyrogallol
  • Vitamin E
  • Ascorbic Acid