Azathioprine intolerance in patients with IBD may be imidazole-related and is independent of TPMT activity

Gastroenterology. 2002 Mar;122(3):838-9. doi: 10.1053/gast.2002.32124.
No abstract available

Publication types

  • Clinical Trial
  • Letter

MeSH terms

  • Azathioprine / adverse effects*
  • Azathioprine / pharmacokinetics
  • Humans
  • Imidazoles / adverse effects
  • Imidazoles / pharmacokinetics
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / pharmacokinetics
  • Inflammatory Bowel Diseases / drug therapy*
  • Inflammatory Bowel Diseases / metabolism*
  • Methyltransferases / metabolism*

Substances

  • Imidazoles
  • Immunosuppressive Agents
  • Methyltransferases
  • thiopurine methyltransferase
  • Azathioprine