Oxidants painting the cysteine chapel: redox regulation of PTPs

Dev Cell. 2002 Mar;2(3):251-2. doi: 10.1016/s1534-5807(02)00132-6.


Growth factors and cytokines appear to stimulate the intracellular production of reactive oxygen species (ROS). Evidence suggests that this alteration in the cellular redox state is essential for downstream signaling, but the precise mechanism has remained elusive. A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases.

Publication types

  • Review

MeSH terms

  • Cysteine / metabolism*
  • Oxidants / metabolism*
  • Oxidation-Reduction
  • Protein Tyrosine Phosphatases / metabolism*


  • Oxidants
  • Protein Tyrosine Phosphatases
  • Cysteine