Apoptosome: the seven-spoked death machine

Dev Cell. 2002 Mar;2(3):256-7. doi: 10.1016/s1534-5807(02)00137-5.


A paper in the February issue of Molecular Cell describes the structure of the apoptosome, a multicomponent death machine, deciphered by cryoelectron microscopy. This structure explains the assembly of the machine, the tentative location of the subcomponents, and proposes a mechanism for initiating the death signal.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Caspases / metabolism*


  • Caspases