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Review
, 2 (3), 256-7

Apoptosome: The Seven-Spoked Death Machine

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Review

Apoptosome: The Seven-Spoked Death Machine

Guy S Salvesen et al. Dev Cell.

Abstract

A paper in the February issue of Molecular Cell describes the structure of the apoptosome, a multicomponent death machine, deciphered by cryoelectron microscopy. This structure explains the assembly of the machine, the tentative location of the subcomponents, and proposes a mechanism for initiating the death signal.

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