Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation

Lancet. 2002 Feb 23;359(9307):677-8. doi: 10.1016/S0140-6736(02)07807-8.


Ventricular fibrillation is the main mechanism of sudden cardiac death, but the source of its spontaneous initiation has not been mapped. 16 patients were investigated by electrography and radiofrequency ablation after resuscitation from recurrent idiopathic ventricular fibrillation. Triggers of ventricular fibrillation originated from various locations within the Purkinje system in 12 patients and from the ordinary myocardial muscle in four. The accuracy of mapping was confirmed by acute elimination of triggers by radiofrequency delivery, and there was no recurrence of ventricular fibrillation in 14 patients. Long-term follow-up is necessary to establish that ablation is curative and avoids use of a defibrillator.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Catheter Ablation
  • Electrocardiography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Purkinje Fibers / physiology*
  • Ventricular Fibrillation / physiopathology*
  • Ventricular Fibrillation / therapy