Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection

Microbes Infect. 2002 Feb;4(2):225-35. doi: 10.1016/s1286-4579(01)01534-9.


Actinobacillus pleuropneumoniae causes porcine pleuropneumonia, a highly contagious disease for which there is no effective vaccine. This review considers how adhesins, iron-acquisition factors, capsule and lipopolysaccharide, RTX cytotoxins and other potential future vaccine components contribute to colonisation, to avoidance of host clearance mechanisms and to damage of host tissues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actinobacillus Infections / microbiology*
  • Actinobacillus Infections / veterinary
  • Actinobacillus pleuropneumoniae / pathogenicity*
  • Actinobacillus pleuropneumoniae / physiology
  • Animals
  • Bacterial Capsules / metabolism
  • Bacterial Outer Membrane Proteins / metabolism
  • Lipopolysaccharides / metabolism
  • Prevalence
  • Swine / microbiology*
  • Swine Diseases / microbiology
  • Virulence


  • Bacterial Outer Membrane Proteins
  • Lipopolysaccharides