The purpose of this study was to examine the relationship between perceived social support and general well-being in early adolescents and to test two variables, hopefulness and self-esteem, that theoretically mediate this relationship. The final sample consisted of 142 adolescents, ages 12 to 14, who responded to instruments measuring perceived social support hopefulness, self-esteem, and general well-being in classroom settings. Correlational analysis supported the five hypothesized relationships. A series of regression analyses described by Baron and Kenny indicated that hopefulness and self-esteem each were mediators of the relationship between social support and well-being. Implications for nursing practice are addressed.