Complement dependence of localisation of aggregated IgG in germinal centres

Scand J Immunol. 1975;4(4):343-47. doi: 10.1111/j.1365-3083.1975.tb02635.x.


In vivo decomplementation of mice with cobra factor completely prevented trapping of aggregated human IgG within splenic germinal centres. Observations of the intrasplenic position of the aggregated material within 8 hr of its injection into normal and decomplemented mice suggest that the early phase of localisation in germinal centres depends on binding to lymphocyte C3 receptors.

MeSH terms

  • Animals
  • Binding Sites
  • Complement C3 / metabolism*
  • Complement System Proteins / metabolism*
  • Female
  • Germ Cells / immunology*
  • Hot Temperature
  • Immunoglobulin G / metabolism*
  • Injections, Intraperitoneal
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Snake Venoms / administration & dosage
  • Snake Venoms / pharmacology
  • Spleen / immunology*


  • Complement C3
  • Immunoglobulin G
  • Snake Venoms
  • Complement System Proteins