Technology evaluation: APC-8015, Dendreon

Curr Opin Mol Ther. 2002 Feb;4(1):76-9.

Abstract

Dendreon (formerly Activated Cell Therapy), in association with the Mayo Clinic, is developing the dendritic cell therapy APC-8015 (Provenge) for the potential treatment of hormone-refractory prostate cancer [284376]. Phase III trials were initiated in January 2000 [353557], and in July 2001 Dendreon anticipated that preliminary results would be available by the end of the year [417283], [427591]. As of September 2001, Dendreon was planning tofile a BLA in 2002 [421356]. Provenge involves the use of a proprietary recombinant antigen derived from prostatic acid phosphatase, found in approximately 95% of prostate cancers. The target antigen is combined with the patient's own dendritic cells and reinfused into the patient to stimulate an immune response [406383]. In November 1999, Dendreon received US-05976546, which covers the composition of the prostate tumor antigen engineered by Dendreon to help stimulate the immune system [347885]. In August 2000, Dendreon received US-06080409, entitled 'Immunostimulatory composition', which relates to the method by which Dendreon's vaccines stimulate the T-cell arm of the immune system tofight cancer [379085]. In April 2001, Dendreon was awarded US-06210662 covering the therapeutic composition of APC-8015 [406383].

Publication types

  • Review

MeSH terms

  • Acid Phosphatase
  • Antigen Presentation
  • Antigens, Neoplasm / genetics
  • Cancer Vaccines / metabolism
  • Cancer Vaccines / pharmacology
  • Cancer Vaccines / therapeutic use*
  • Cancer Vaccines / toxicity
  • Clinical Trials as Topic
  • Dendritic Cells / immunology
  • Humans
  • Male
  • Prostatic Neoplasms / immunology
  • Prostatic Neoplasms / therapy*
  • Protein Tyrosine Phosphatases / genetics
  • Protein Tyrosine Phosphatases / immunology
  • T-Lymphocytes / immunology

Substances

  • Antigens, Neoplasm
  • Cancer Vaccines
  • Acid Phosphatase
  • prostatic acid phosphatase
  • Protein Tyrosine Phosphatases