Age and regional cerebral blood flow in schizophrenia: age effects in anterior cingulate, frontal, and parietal cortex

J Neuropsychiatry Clin Neurosci. Winter 2002;14(1):19-24. doi: 10.1176/jnp.14.1.19.


Positron emission tomography ([(15)O] water PET) was used to examine the relationship between age and regional cerebral blood flow (rCBF) in schizophrenia. Forty-nine unmedicated male patients, ages 20-51, underwent imaging during an eyes-closed resting condition. Negative correlations were observed between age and rCBF in the anterior cingulate, as well as in frontal (Brodmann area 8) and parietal cortex (area 40) bilaterally. The observation of reduced rCBF in the anterior cingulate with increased age is consistent with previous findings in healthy subjects. In contrast, the reduced flow observed in the frontal and parietal regions may be unique to schizophrenia.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aging / physiology*
  • Cerebrovascular Circulation / physiology*
  • Frontal Lobe / blood supply*
  • Frontal Lobe / diagnostic imaging
  • Gyrus Cinguli / blood supply*
  • Gyrus Cinguli / diagnostic imaging
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Oxygen Radioisotopes
  • Parietal Lobe / blood supply*
  • Parietal Lobe / diagnostic imaging
  • Schizophrenia / diagnostic imaging
  • Schizophrenia / physiopathology*
  • Tomography, Emission-Computed


  • Oxygen Radioisotopes