Evaluation of cerebral perfusion parameters measured by perfusion CT in chronic cerebral ischemia: comparison with xenon CT

J Comput Assist Tomogr. Mar-Apr 2002;26(2):272-8. doi: 10.1097/00004728-200203000-00019.


Purpose: The purpose of this work was to evaluate the usefulness of perfusion CT in the evaluation of patients with chronic cerebral ischemia by comparing it with xenon CT (Xe-CT).

Method: Cerebral blood flow (CBF) of perfusion CT (CBFper) and time to peak (TTP) were compared with the CBF of Xe-CT (CBFxe) in 18 patients. Cerebral blood volume (CBV) was compared with cerebral vascular reserve (CVR) in 10 of 18 patients who underwent pre- and postacetazolamide Xe-CT.

Results: CBFper and TTP demonstrated a high correlation with CBFxe in relative values by side-to-side comparisons (r = 0.743, p < 0.0001 and r = -0.760, p < 0.0001, respectively). There was a negative correlation between relative CBV and relative CVR (r = -0.637, p = 0.0025). Visually, territories with delayed TTP corresponded well to those of decreased CBFxe, but these territories tended to be larger in TTP maps.

Conclusion: Perfusion CT is a useful tool to evaluate chronic hemodynamic disturbance and can be an alternative method for those using acetazolamide challenge.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Brain Ischemia / pathology*
  • Cerebral Cortex / blood supply*
  • Cerebral Cortex / pathology
  • Chronic Disease
  • Female
  • Hemodynamics
  • Humans
  • Male
  • Middle Aged
  • Regional Blood Flow
  • Tomography, X-Ray Computed / methods*
  • Xenon


  • Xenon