Sentinel lymph node biopsy for cutaneous head and neck melanomas

Arch Otolaryngol Head Neck Surg. 2002 Mar;128(3):285-91. doi: 10.1001/archotol.128.3.285.


Objective: To report the results of sentinel lymph node biopsy (SLNB) for cutaneous head and neck melanomas (CMHNs).

Design: Consecutive series followed for a median of 20 months.

Setting: Tertiary cancer care center.

Patients: Fifty-six individuals with clinically node-negative CMHN, median Breslow thickness, 2.6 mm (range, 0.2-20.0 mm).

Interventions: Preoperative technetium 99m sulfur colloid lymphoscintigraphy (PLSG) followed within 4 hours by intraoperative handheld gamma probe localization (IHGP). Intraoperative injection of 1% isosulfan blue dye (IBD) was used in 48 patients. Immediate completion nodal dissection was performed for metastatic SLNs on intraoperative frozen section analysis and monitoring for negative SLNs.

Main outcome measures: Rate of SLN identification, SLN and non-SLN positivity, same-basin recurrence, and disease-specific and recurrence-free survival.

Results: Combination of IHGP and IBD improved SLN identification to 96% from 93% for IHGP and 73% for IBD alone. Four patients had a positive SLN on frozen section analysis. A negative SLNB correctly predicted regional nodal control in 47 of 48 patients but missed 1 of 5 patients who had regional lymphatic disease. All 4 patients who failed SLNB remain alive and free of recurrent disease. Two-year Kaplan-Meier disease-specific and relapse-free survival was 91% and 88%, respectively. Two-year disease-specific survival was 93% for SLN-negative patients and 50% for SLN-positive patients (P=.20).

Conclusions: Combining PLSG with IHGP and IBD improves the success rate of SLNB. Although SLNB is a reliable indicator of the status of the draining lymphatic basins in CMHN, patients with negative SLNs must be observed for longer periods to understand the true implications of the procedure.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Female
  • Frozen Sections
  • Head and Neck Neoplasms / diagnosis
  • Head and Neck Neoplasms / mortality
  • Head and Neck Neoplasms / pathology*
  • Humans
  • Male
  • Melanoma / diagnosis
  • Melanoma / mortality
  • Melanoma / pathology*
  • Middle Aged
  • Rosaniline Dyes
  • Sentinel Lymph Node Biopsy*
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / mortality
  • Skin Neoplasms / pathology*
  • Survival Rate
  • Technetium Tc 99m Sulfur Colloid


  • Rosaniline Dyes
  • iso-sulfan blue
  • Technetium Tc 99m Sulfur Colloid