Use of mitomycin C in the treatment of corneal conjunctival intraepithelial neoplasia

Clin Exp Ophthalmol. 2002 Apr;30(2):94-8. doi: 10.1046/j.1442-6404.2002.00497.x.


Purpose: To evaluate the efficacy of topical mitomycin C as a treatment of corneal conjunctival intraepithelial neoplasia.

Methods: An open prospective analysis of 20 cases of corneal conjunctival intraepithelial neoplasia with recurrent disease (17 patients) or refusing surgery (three patients) were treated with topical mitomycin C. Treatment was with mitomycin C eye drops, either 0.02% or 0.04%, four times daily for 1 week followed by a week off the cycle then repeated for a second week. Patients were examined weekly until the lesions were eradicated.

Results: Clinical resolution of disease occurred in 18/20 cases. The mean time to resolution was 4.5 weeks, the mean number of cycles of treatment was two. Average follow up was 13 months with four cases of recurrent disease. These four cases were retreated with complete resolution in two cases. Epithelial toxicity occurred in 10/20 eyes and lid toxicity in two cases. There were no long-term complications on discontinuing mitomycin C.

Conclusions: Mitomycin C is effective in inducing regression of corneal conjunctival intraepithelial neoplasia. Complications are common but self-limiting. An optimal regimen is still to be established.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / adverse effects
  • Antibiotics, Antineoplastic / therapeutic use*
  • Carcinoma in Situ / drug therapy*
  • Conjunctival Neoplasms / drug therapy*
  • Corneal Diseases / drug therapy*
  • Eye Neoplasms / drug therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage
  • Mitomycin / adverse effects
  • Mitomycin / therapeutic use*
  • Neoplasm Recurrence, Local / drug therapy
  • Ophthalmic Solutions
  • Prospective Studies
  • Treatment Outcome


  • Antibiotics, Antineoplastic
  • Ophthalmic Solutions
  • Mitomycin