Intrathecal IgM synthesis in neurologic diseases: relationship with disability in MS

Neurology. 2002 Mar 12;58(5):824-6. doi: 10.1212/wnl.58.5.824.


The authors studied the intrathecal IgM synthesis (ITMS) in paired sera and CSF samples from 65 patients with MS, 28 with CNS infection, 40 with other neurologic diseases and eight control subjects. ITMS was found in 30 patients with MS and in 20 with CNS infection, but not in patients with other neurologic diseases or in control subjects. In infectious samples, the ITMS is likely a primary response. In MS group, it was associated with higher Expanded Disability Status Scale index (p = 0.017).

MeSH terms

  • Adult
  • Central Nervous System Infections / blood
  • Central Nervous System Infections / cerebrospinal fluid
  • Central Nervous System Infections / immunology*
  • Disability Evaluation
  • Female
  • Humans
  • Immunoglobulin M / blood*
  • Immunoglobulin M / cerebrospinal fluid*
  • Male
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / immunology*


  • Immunoglobulin M