Nausea and vomiting of pregnancy. Evidence-based treatment algorithm

Can Fam Physician. 2002 Feb;48:267-8, 277.


Question: One of my patients suffers from a moderate-to-severe form of morning sickness. She responded only partially to doxylamine and pyridoxine (Dicletin), and I wish to try adding another medication. What should my priority be?

Answer: An algorithm used by Motherisk to manage thousands of patients takes a hierarchical approach to this condition. This approach is evidence based with regard to fetal safety as well as efficacy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms
  • Antiemetics / therapeutic use*
  • Evidence-Based Medicine*
  • Female
  • Humans
  • Nausea / etiology
  • Nausea / therapy*
  • Pregnancy
  • Pregnancy Complications / etiology
  • Pregnancy Complications / therapy*
  • Vomiting / etiology
  • Vomiting / therapy*


  • Antiemetics