The other half of Hebb: K+ channels and the regulation of neuronal excitability in the hippocampus

Mol Neurobiol. 2002 Feb;25(1):51-66. doi: 10.1385/MN:25:1:051.


Historically, much attention has focused on the mechanisms of activity-dependent plasticity since the description of long-term potentiation by Bliss and Lomo in the early 1970s, while extrasynaptic changes have received much less interest. However, recent work has concentrated on the role of back-propagating action potentials in hippocampal dendrites in synaptic plasticity. In this review, we focus on the modulation of back-propagating action potentials by K+ currents in the dendrites of hippocampal cells. We described the primary K+-channel subunits and their interacting subunits that most likely contribute to these currents, and how these sites can be regulated by phosphorylation and other mechanisms. In conclusion, we provide a model for an alternative form of coincidence detection through K+ channels in the hippocampus.

Publication types

  • Review

MeSH terms

  • Action Potentials
  • Animals
  • Cytoskeletal Proteins / physiology
  • Dendrites / physiology
  • Hippocampus / cytology
  • Hippocampus / physiology*
  • Humans
  • Ion Transport
  • MAP Kinase Signaling System
  • Mice
  • Models, Molecular
  • Models, Neurological
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / physiology*
  • Neuronal Plasticity / physiology*
  • Phosphorylation
  • Potassium / physiology*
  • Potassium Channels / chemistry
  • Potassium Channels / classification
  • Potassium Channels / physiology*
  • Potassium Channels, Voltage-Gated*
  • Protein Kinases / physiology
  • Protein Processing, Post-Translational
  • Protein Subunits
  • Shal Potassium Channels
  • Synapses / physiology


  • Cytoskeletal Proteins
  • Nerve Tissue Proteins
  • Potassium Channels
  • Potassium Channels, Voltage-Gated
  • Protein Subunits
  • Shal Potassium Channels
  • Protein Kinases
  • Potassium