A novel dic(1;10) in a patient with myelodysplastic syndrome

Constantina Sambani; Roberta La Starza; Chryssa Stavropoulou; Kalliopi N Manola; Nicholas Harhalakis; Cristina Mecucci

doi:10.1016/s0165-4608(01)00571-4

A novel dic(1;10) in a patient with myelodysplastic syndrome

Cancer Genet Cytogenet. 2002 Feb;133(1):87-9. doi: 10.1016/s0165-4608(01)00571-4.

Authors

Constantina Sambani¹, Roberta La Starza, Chryssa Stavropoulou, Kalliopi N Manola, Nicholas Harhalakis, Cristina Mecucci

Affiliation

¹ Laboratory of Health Physics & Environmental Hygiene, NCSR Demokritos, Athens, Greece. csambani@mail.demokritos.gr

PMID: 11890996
DOI: 10.1016/s0165-4608(01)00571-4

Abstract

We report on a case of refractory anemia with trilineage dysplasia and an unbalanced der(1)t(1;10) that resulted in trisomy of the long arm of chromosome 1 (1q) and monosomy of the short arm of chromosome 10 (10p). Fluorescence in situ hybridization showed that the rearranged chromosome contained the centromeres of both chromosomes 1 and 10, leading to a dic(1;10). To our knowledge, a dicentric chromosome involving chromosomes 1 and 10 has never been described in hematological malignancies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 10*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Male
Monosomy*
Myelodysplastic Syndromes / genetics*
Trisomy*