Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass

Curr Opin Cell Biol. 2002 Apr;14(2):196-202. doi: 10.1016/s0955-0674(02)00310-1.


Phosphatidylinositol 3-kinase lipid products and the Rho GTPases play a central role in transmitting information from chemotactic receptors to the effectors of cell polarity, and recent advances in the field have allowed us to understand these roles more clearly. Emergent properties of positive and negative regulation of these molecules may account for the establishment of cell polarity during chemotaxis for a wide range of cells from Dictyostelium to fibroblasts to neutrophils.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Polarity / physiology*
  • Chemotaxis / physiology*
  • Humans
  • Lysophospholipids*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Platelet-Derived Growth Factor / metabolism
  • Signal Transduction / physiology*
  • Sphingosine / analogs & derivatives*
  • Sphingosine / metabolism
  • rho GTP-Binding Proteins / metabolism*


  • Lysophospholipids
  • Platelet-Derived Growth Factor
  • sphingosine 1-phosphate
  • Phosphatidylinositol 3-Kinases
  • rho GTP-Binding Proteins
  • Sphingosine