Abstract
Recent investigation of the DNA-damage checkpoint in several organisms has highlighted the conservation of this pathway. The checkpoint's signal transduction pathway consists of four conserved classes of molecules: two large protein kinases having homology to phosphatidylinositol 3-kinases, three "sensor" proteins with homology to proliferating cell nuclear antigen, two serine/threonine (S/T) kinases, and two adaptors for the S/T kinases. This review compares the role of these four classes of checkpoint proteins in humans and model organisms.
MeSH terms
-
Adaptor Proteins, Signal Transducing*
-
Animals
-
Carrier Proteins / metabolism*
-
Cell Cycle Proteins / metabolism
-
Checkpoint Kinase 1
-
Checkpoint Kinase 2
-
DNA Damage / physiology*
-
DNA Repair Enzymes
-
DNA-Binding Proteins*
-
Endonucleases
-
Humans
-
Phosphatidylinositol 3-Kinases / metabolism*
-
Proliferating Cell Nuclear Antigen / metabolism
-
Protein Kinases / metabolism
-
Protein-Serine-Threonine Kinases / metabolism
-
Saccharomyces cerevisiae Proteins
-
Schizosaccharomyces pombe Proteins
-
Signal Transduction / physiology*
-
Xenopus Proteins*
Substances
-
Adaptor Proteins, Signal Transducing
-
CLSPN protein, Xenopus
-
CLSPN protein, human
-
Carrier Proteins
-
Cell Cycle Proteins
-
DNA-Binding Proteins
-
Proliferating Cell Nuclear Antigen
-
Saccharomyces cerevisiae Proteins
-
Schizosaccharomyces pombe Proteins
-
Xenopus Proteins
-
hus1 protein, S pombe
-
rad9 protein
-
Protein Kinases
-
Phosphatidylinositol 3-Kinases
-
Checkpoint Kinase 2
-
CHEK2 protein, human
-
Cds1 protein, S pombe
-
Checkpoint Kinase 1
-
Protein-Serine-Threonine Kinases
-
Endonucleases
-
RAD1 protein, S cerevisiae
-
DNA Repair Enzymes