A unified view of the DNA-damage checkpoint

Curr Opin Cell Biol. 2002 Apr;14(2):237-45. doi: 10.1016/s0955-0674(02)00312-5.

Abstract

Recent investigation of the DNA-damage checkpoint in several organisms has highlighted the conservation of this pathway. The checkpoint's signal transduction pathway consists of four conserved classes of molecules: two large protein kinases having homology to phosphatidylinositol 3-kinases, three "sensor" proteins with homology to proliferating cell nuclear antigen, two serine/threonine (S/T) kinases, and two adaptors for the S/T kinases. This review compares the role of these four classes of checkpoint proteins in humans and model organisms.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Carrier Proteins / metabolism*
  • Cell Cycle Proteins / metabolism
  • Checkpoint Kinase 1
  • Checkpoint Kinase 2
  • DNA Damage / physiology*
  • DNA Repair Enzymes
  • DNA-Binding Proteins*
  • Endonucleases
  • Humans
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Proliferating Cell Nuclear Antigen / metabolism
  • Protein Kinases / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • Signal Transduction / physiology*
  • Xenopus Proteins*

Substances

  • Adaptor Proteins, Signal Transducing
  • CLSPN protein, Xenopus
  • CLSPN protein, human
  • Carrier Proteins
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Proliferating Cell Nuclear Antigen
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • Xenopus Proteins
  • hus1 protein, S pombe
  • rad9 protein
  • Protein Kinases
  • Phosphatidylinositol 3-Kinases
  • Checkpoint Kinase 2
  • CHEK2 protein, human
  • Cds1 protein, S pombe
  • Checkpoint Kinase 1
  • Protein-Serine-Threonine Kinases
  • Endonucleases
  • RAD1 protein, S cerevisiae
  • DNA Repair Enzymes