Synthesis of 188 Re-labelled long chain alkyl diaminedithiol for therapy of liver cancer

Nucl Med Commun. 2002 Mar;23(3):237-42. doi: 10.1097/00006231-200203000-00006.


Radioisotope-labelled lipiodol has been used in the therapy of liver cancer. Recently a lipiodol solution of 188Re-labelled diaminedithiol (DD) has been reported to show a high uptake in the liver cancer. We synthesized long-chain alkyl DD derivatives to improve their uptake and retention in tissue. As the length of the alkyl chain increased, tissue uptake and retention also increased due to hydrophobic interaction with lipiodol. Among the synthesized compounds, the lipiodol solution of 188Re-HDD, the DD derivative with the longest side chain (C16), is a promising agent for therapy of liver cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Iodized Oil / pharmacokinetics*
  • Liver Neoplasms / metabolism*
  • Liver Neoplasms / radiotherapy
  • Lung / metabolism
  • Mice
  • Mice, Inbred ICR
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / pharmacokinetics*
  • Organometallic Compounds / therapeutic use
  • Radiopharmaceuticals / chemical synthesis*
  • Radiopharmaceuticals / pharmacokinetics*
  • Radiopharmaceuticals / therapeutic use
  • Tissue Distribution


  • Organometallic Compounds
  • Radiopharmaceuticals
  • rhenium diaminedithiol
  • Iodized Oil