Pectenotoxin-2 synthetic studies. 1. Alkoxide precoordination to [Rh(NBD)(DIPHOS-4)]BF(4) allows directed hydrogenation of a 2,3-dihydrofuran-3-ol without competing furan production

Leo A Paquette; Xiaowen Peng; Dmitriy Bondar

doi:10.1021/ol010302l

Pectenotoxin-2 synthetic studies. 1. Alkoxide precoordination to [Rh(NBD)(DIPHOS-4)]BF(4) allows directed hydrogenation of a 2,3-dihydrofuran-3-ol without competing furan production

Org Lett. 2002 Mar 21;4(6):937-40. doi: 10.1021/ol010302l.

Authors

Leo A Paquette¹, Xiaowen Peng, Dmitriy Bondar

Affiliation

¹ Evans Chemical Laboratories, The Ohio State University, Columbus, Ohio 43210, USA. paquette.1@osu.edu

PMID: 11893190
DOI: 10.1021/ol010302l

Abstract

[reaction: see text] The alkoxide-directed hydrogenation shown is reported as a key step in a concise synthesis of a fully functionalized precursor to the C29-C40 F/G sector of pectenotoxin-2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Furans / chemical synthesis*
Furans / chemistry
Hydrogen / chemistry*
Macrolides
Magnetic Resonance Spectroscopy
Oxides / chemistry*
Pyrans / chemical synthesis*
Pyrans / chemistry

Substances

Antineoplastic Agents
Furans
Macrolides
Oxides
Pyrans
Hydrogen
pectenotoxin 2