Synthesis of marine sponge bisindole alkaloids dihydrohamacanthins

Org Lett. 2002 Mar 21;4(6):941-3. doi: 10.1021/ol020002j.

Abstract

[structure: see text] A convergent synthesis of the marine sponge bisindole alkaloids dihydrohamacanthins is described. The synthesis centers on the construction of 3,5- and 3,6-linked pyrazinones and their reduction to the requisite piperazinones with sodium cyanoborohydride.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Indole Alkaloids / chemical synthesis*
  • Indole Alkaloids / chemistry
  • Molecular Structure
  • Porifera

Substances

  • Indole Alkaloids