RNAi: nature abhors a double-strand

Curr Opin Genet Dev. 2002 Apr;12(2):225-32. doi: 10.1016/s0959-437x(02)00290-3.


In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.

Publication types

  • Review

MeSH terms

  • Animals
  • Endoribonucleases / physiology*
  • RNA, Double-Stranded / physiology*
  • RNA, Messenger / metabolism*
  • RNA-Dependent RNA Polymerase / physiology*
  • Ribonuclease III


  • RNA, Double-Stranded
  • RNA, Messenger
  • RNA-Dependent RNA Polymerase
  • Endoribonucleases
  • Ribonuclease III