AMOP, a protein module alternatively spliced in cancer cells

Trends Biochem Sci. 2002 Mar;27(3):113-5. doi: 10.1016/s0968-0004(01)02049-7.


This article describes a new extracellular domain--AMOP, for adhesion-associated domain in MUC4 and other proteins. This domain occurs in putative cell adhesion molecules and in some splice variants of MUC4. MUC4 splice variants are overexpressed in several tumours; in particular, they are highly expressed in pancreatic carcinomas but not in normal pancreas. The presence of AMOP in cell adhesion molecules could be indicative of a role for this domain in adhesion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing*
  • Amino Acid Sequence
  • Biomarkers, Tumor / metabolism
  • Cell Adhesion / physiology
  • Humans
  • Molecular Sequence Data
  • Mucin-4
  • Mucins / genetics*
  • Pancreatic Neoplasms / genetics*
  • Prognosis
  • Sequence Homology, Amino Acid


  • Biomarkers, Tumor
  • MUC4 protein, human
  • Mucin-4
  • Mucins