Alpha2-adrenergic receptor agonists as analgesics

Curr Top Med Chem. 2001 Aug;1(3):193-7. doi: 10.2174/1568026013395182.


Alpha2-adrenergic receptor agonists are analgesic agents, and the alpha2-adrenergic agonist clonidine has been used in clinical studies for regional analgesia after intrathecal administration. We review here recent developments concerning the structure activity relationships of a new class of potent alpha2-adrenergic agonists and their use as analgesic agents. The effect of structure upon cardiovascular side-effects is also monitored, such as the prolongation of the QT portion of the cardiac action potential.

Publication types

  • Review

MeSH terms

  • Adrenergic alpha-2 Receptor Agonists*
  • Analgesics / chemistry*
  • Analgesics / pharmacology
  • Animals
  • Catecholamines / chemistry
  • Catecholamines / pharmacology
  • Clonidine / chemistry
  • Clonidine / pharmacology
  • Humans
  • Structure-Activity Relationship


  • Adrenergic alpha-2 Receptor Agonists
  • Analgesics
  • Catecholamines
  • Clonidine