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, 30 (4), 363-4

Micro RNAs Are Complementary to 3' UTR Sequence Motifs That Mediate Negative Post-Transcriptional Regulation

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Micro RNAs Are Complementary to 3' UTR Sequence Motifs That Mediate Negative Post-Transcriptional Regulation

Eric C Lai. Nat Genet.

Abstract

Micro RNAs are a large family of noncoding RNAs of 21-22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.

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