[Prospects for developing treatment of uveal melanoma from the position of modern carcinogenesis concepts]

Vestn Oftalmol. Jan-Feb 2002;118(1):32-5.
[Article in Russian]


Immunohistochemical studies of regulator proteins p53, Bcl-2, Bax, Ki-67, and CD-95L showed that apoptosis suppression, allowing unlimited proliferation of tumor cells, plays an important role in the carcinogenesis of uveal melanoma. This fact dictates the need of including drugs arresting suppression or inducing apoptosis in therapeutic protocols for uveal melanoma. Prognostic significance of p53, Bcl-2, Bax, and CD-95L was demonstrated. Each of the peptides can be used as a prognostic marker.

Publication types

  • English Abstract

MeSH terms

  • Apoptosis
  • Cell Transformation, Neoplastic*
  • Humans
  • Immunohistochemistry
  • Melanoma / metabolism
  • Melanoma / pathology
  • Melanoma / physiopathology*
  • Tumor Suppressor Proteins / metabolism
  • Uveal Neoplasms / metabolism
  • Uveal Neoplasms / pathology
  • Uveal Neoplasms / physiopathology*


  • Tumor Suppressor Proteins