Studies show that children of alcoholics constitute a population at-risk commonly for poor performance, skipping school days, and school drop out. The focus of the present study was to examine a variety of direct outcome variables measuring academic performance among a sample of 226 children, 108 of them from parents who misused alcohol in Cadiz. Parents were outpatients of a Health Service and received treatment for the drinking problem; 118 students were children of nonalcoholic parents attending the same schools as the children of alcoholic parents. Both groups were compared on age, sex, school grade, and social environment. The study identified five variables on which performance by children of alcoholic parents was poorer: intelligence, repeating a grade, low academic performance, skipping school days, and dropping out of school.