Role of the NF-kappaB pathway in the pathogenesis of human disease states

Curr Mol Med. 2001 Jul;1(3):287-96. doi: 10.2174/1566524013363816.

Abstract

The NF-kappaB family consists of a group of inducible transcription factors which regulate immune and inflammatory responses and protect cells from undergoing apoptosis in response to cellular stress. A number of signal transduction cascades can activate the NF-kappaB pathway to result in the translocation of the NF-kappaB proteins from the cytoplasm to the nucleus where they activate the expression of specific cellular genes. In this review, we discuss cellular genes which are regulated by NF-kappaB and disease states which are associated with constitutive activation of the NF-kappaB pathway. Strategies to prevent prolonged activation of the NF-kappaB pathway are also discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / etiology
  • Arteriosclerosis / etiology
  • Arthritis, Rheumatoid / etiology
  • Asthma / etiology
  • Diabetes Mellitus / etiology
  • Disease / etiology*
  • Gene Expression Regulation
  • Humans
  • Incontinentia Pigmenti / etiology
  • Inflammation / etiology
  • Inflammatory Bowel Diseases / etiology
  • Models, Biological
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / genetics
  • NF-kappa B / physiology*
  • Neoplasms / etiology
  • Signal Transduction

Substances

  • NF-kappa B