Kinetics of antibody production to group A and group C meningococcal polysaccharide vaccines administered during the first six years of life: prospects for routine immunization of infants and children

J Infect Dis. 1979 Nov;140(5):690-7. doi: 10.1093/infdis/140.5.690.


A cohort of infants, previously immunized once or twice between three and 12 months of age with vaccines containing polysaccharide of groups A and C Neisseria meningitidis, received boosters at two and five and one-half years of age with bivalent A/C vaccine. Antibody concentrations were measured by a radioactive antigen-binding assay. Concentrations of antibody to groups A and C N. meningitidis were 5.59 and 2.86 microgram/ml, respectively, by four years of age. After booster immunization at five and one-half years of age, concentrations of antibody to groups A and C N. meningitidis increased to 15.67 and 7.59 microgram/ml, respectively. Protective levels of antibody to group A meningococci may be achievable throughout early childhood by routine immunization with the A vaccine. Although the group C vaccine is effective in control of epidemics, the rapid decline in the concentration of antibody to group C meningococci following immunization of young children suggests that protection may not be long-lasting.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging
  • Antibodies, Bacterial / biosynthesis*
  • Bacterial Vaccines / administration & dosage*
  • Child
  • Child, Preschool
  • Humans
  • Immunization
  • Immunization, Secondary
  • Infant
  • Kinetics
  • Neisseria meningitidis / immunology*
  • Patient Compliance
  • Polysaccharides, Bacterial / immunology*


  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Polysaccharides, Bacterial